Txav mus dhau, berberine!Tshawb nrhiav cov khoom siv txuas ntxiv tom ntej xa cov khoom lag luam superabolic nrog kev nqus cov pa taws thiab thev taus.
Rau xyoo,Berberine HCL, lub ntuj sib xyaw pom nyob rau hauv cov nroj tsuag zoo li kub thiab barbers, tau raug lees paub rau nws cov peev xwm los txhawb cov ntshav qab zib muaj kev noj qab haus huv zoo dua thiab kev noj qab haus huv. Txawm li cas los xij, nws cov thoob plaws kev saws me nyuam tau raug teeb meem los ntawm cov nyom tseem ceeb:Tsis zoo Bioavailability thiab nquag kis pa taws kev phiv.Qhov no txhais tau ntau ntawm kev noj koob tshuaj tsis ua tau zoo nqus, thiab cov neeg siv feem ntau tau ntsib tsis xis nyob.
NkagIriYdroberberine (DHB), kev tshawb fawb tau txais kev tshawb fawb txog hydrogenated hydrogenated ntawm berberine. DHB piv txog ib qho tseem ceeb tshaj tawm, muab cov txiaj ntsig zoo ntawm berberine tab sis nrog kev hloov pauv zoo duaKev nqus tau thiab lub zog txo cov teeb meem ntawm kev zom zom.
Xauv Cov Kev Pab metabolic: Science-thaub qab ua tau zoo ntawm Dihydr BoberBertube
Dihydroberberine tsis yog kev txhim kho theoretical; Nws txhim kho Bioavailability txhais ncaj qha rau hauv cov txiaj ntsig metabolic, txhawb los ntawm kev tshawb fawb nruj:
Ⅰsuperior dej ntshav qab zib
Cov txiaj ntsig tseem ceeb ntawm DHB cov lus dag nyob rau hauv nws lub peev xwm los ua kom tau txais txiaj ntsig zoo txog cov ntshav qab zib. Nws cov txiaj ntsig siab heev ua kom muaj ntau qhov chaw ua kom nquag mus txog ntawm cov ntshav thiab lub hom phiaj ntaub so ntswg.
Yam povthawj: Kev tshawb fawb pom tau tias DHB tau zoo txhim kho glucose pov tseg thiab insulin rhiab heev. Kev tshawb fawb luam tawm nyob rau hauv cov neeg ua yeeb yam ntawm cov qauv ntshav qab zib thiab cov qauv insulin tsis zoo, qhia txog nws lub peev xwm rau kev tswj hwm metabolic tuag.[1]
Ⅱ Txhim Kho Insulin rhiab
Los ntawm kev txhim kho lub cev siv cov insulin, DHB yuav pab tau cov ntshav kom tau txais cov ntshav ua tau los ntawm cov hlab ntshav.
Pov Thawj:Tus kws kho tshuab cuam tshuam nrog DHB ua kom tau zoo amp-activated protein kinase (ampk), feem ntau hu ua "Metabolic Master hloov." Ua kom Ampk stimulates qabzib ntau dua hauv cov leeg pob txha thiab lwm cov ntaub so ntswg, txhim kho cov insulin rhiab. Qhov kev ua kom muaj zog no yog ib txoj hauv kev zoo rau cov berberine thiab nws cov derivatives zoo li DHB.[1, 2]
Proported Txhawb kev noj qab haus huv lipid profiles
Dhau ntawm cov ntshav qab zib, DHB pab txhawb kom muaj kev saib xyuas kev noj qab haus huv los ntawm kev txhawb nqa cov roj (cholesterol) thiab triglyceride ntau ntau.
Pov Thawj:Cov chaw kuaj mob thiab cov kev tshawb fawb meej meej qhia tau tias DHB ntxiv yuav ua rau txo qis cov roj (cholesterol), thiab cov roj ntsha tsis zoo, "zoo") cov qib roj cholesterol[3]
In ⅳ Kev Tswj Xyuas Cov Nqi Muaj Peev Xwm
Txhim kho cov teeb meem metabolic, tshwj xeeb yog txhim kho insulin rhiab heev, tuaj yeem cuam tshuam zoo ntawm lub cev kev cai.
Pov Thawj:Thaum coj cov kev sim loj ntawm DHB thiab poob phaus zoo li cov roj av metusolism thiab muaj peev xwm ua kom muaj txiaj ntsig zoo hauv kev tswj hwm cov yeeb yam. Kev tshawb fawb ntawm Berberine tsis tu ncua ua rau muaj kev sib txuam ntawm kev txhim kho metabolic tsis muaj zog thiab muaj kev zoo rau lub cev muaj pes tsawg leeg.[4]
Yuav ua li cas siv ihydroberberry ua haujlwm: precision lub hom phiaj ntawm qib cellular
Dihydroberberine cov txiaj ntsig kev cuam tshuam cov kab los ntawm nws cov kev sib txuam nrog cov kab ke tseem ceeb
Ampk ua kom tau
- Tus Masterolic Master Hloov:DHB thawj lub tshuab yog kev ua haujlwm ntawm amp-activated protein kinase (ampk).
- Mechanism:Thaum cov xov tooj ntawm tes muaj zog (ank tsawg, siab amp), ampk ua kom rov qab los kho kom sib npaug. DHB muaj txiaj ntsig zoo mimics Lub xeev qis-zog, ua kom ampk ua kom muaj kev ua haujlwm zoo.
- Qhov tshwm sim:Ua kom ampk pib lub ntsej muag muaj txiaj ntsig ntawm cov txiaj ntsig zoo:
- Nce hallucose uptake:Txhawb txoj kev sib txuas ntawm glut4 cov pa nquam nkoj thauj mus los lub cell membrane nyob rau hauv cov leeg thiab cov roj ntsha, uas pub nkag mus rau hauv.[1, 2]
- Txhim Kho Insulin rhiab heev:Txhim kho cov insulin signaling txoj kev nyob hauv cov insulin recenor.[1, 2]
- Inhibition ntawm gluuconogenesis:Txo cov siab tsim cov piam thaj.[1, 2]
- Kev txhawb nqa Fatty acid oxidation:Txhawb cov roj hlawv ntawm cov rog rau lub zog.[1, 2]
Ⅱ Modulating plab microbiota
Kev Tshawb Fawb Tawm Tsam cov berberine compounds, suav nrog DHB, yuav muaj kev cuam tshuam zoo rau cov muaj pes tsawg leeg thiab ua haujlwm ntawm cov kab mob plab. Kev noj qab haus huv plab microbiome yog nce txuas rau kev txhim kho metabolic kev noj qab haus huv thiab cov kua txiv kablib.[6](Nco tseg: thaum tsim tsa rau Berberine, cov tshuab no yog nquag yog tshawb fawb rau DHB tshwj xeeb).
Ⅲ Tiv thaiv cov teebmeem & antioxidant cuam tshuam
Mob mob ntev li lawb ntawv thiab oxidative kev nyuaj siab yog qhov qhia pom ntawm cov metabolic tsis sib xws. DHB cov khoom pov thawj kev tawm tsam los tiv thaiv thiab cov tshuaj tiv thaiv kab mob, uas tuaj yeem pab txhawb nws cov kev tiv thaiv tag nrho cov kev cuam tshuam los ntawm kev txo cov txheej txheem kev puas tsuaj no.
Kev Nyab Xeeb Profile: Kev zam txim rau meded
Ib qho txiaj ntsig tseem ceeb ntawm dihydroberbereberine tshaj sececters berberine yog nwsTxhim kho thev naus laus zis.
- Txo GI ntxhov siab:Cov kev tsis txaus siab feem ntau nrog Berberine HCL yog qhov tsis xis nyob, nrog rau cramping, roj, raws plab, thiab cem quav. DHB txoj kev nqus zoo dua txhais tau tias tsis muaj kev sib txuas lus tsawg dua mus txog rau txoj hnyuv qis,Ua kom pom qhov tshwm sim los thiab cov kev mob tshwm sim ntau ntxiv. [6]
- Tsim kev nyab xeeb (raws li berberine):Berberine nws tus kheej muaj keeb kwm ntev los ntawm kev siv hauv tshuaj ib txwm muaj thiab muaj kev tshawb fawb ntau ntxiv kev nyab xeeb thaum siv kev nyab xeeb. DHB, raws li ib qho kev tsim kho rau kev nqus tau zoo dua, muaj kev sib zog ua lub hauv paus no.
- Kev sib cuam tshuam yeeb tshuaj:Zoo li Berberine, DHB yuav cuam tshuam nrog qee cov tshuaj metabolized los ntawm CYP450 cov ntshav, feem ntau ntawm cov ntshav noj, thiab immunosuppressants (piv txwv li, cyclosporine).Kev sab laj nrog tus kws kho mob yog qhov tseem ceeb ua ntej pib DHB, tshwj xeeb tshaj yog rau cov tib neeg ntawm kev noj tshuaj.
- Pom zoo siv:Cov koob tshuaj zoo ntawm DHB ntau li ntawm100mg rau 200mg ib zaug lossis ob zaug ib hnub, tseem ceeb dua li 500mg peb zaug ib hnub twg yuav tsum muaj rau berberine hcl, txuas ntxiv pab txhawb rau nws txoj kev thev taus.[6]
- Cev xeeb tub & lactation:Kev nyab xeeb thaum cev xeeb tub thiab pub mis niam mis tau tsis tau tsim. Zam kev siv.
IriYdroberberine (DHB) tsis yog ib qho kev xaiv rau Bergiaine; Nws sawv cev rau kev hloov pauv ntawm qhov kev sib xyaw ntuj ntuj no. Los ntawm kev kov yeej cov kev txwv tseem ceeb ntawm kev nqus tau tsis zoo thiab gi tsis kam muab cov txiaj ntsig metabolic - thiab kev tswj hwm ntshav siab zoo - nyob rau hauv ib daim ntawv qhia txog neeg siv. Thim rov qab los ntawm kev ua pov thawj scientific thiab txig ua ke nrog kev ua lag luam kev noj qab haus huv loj, ua rau muaj kev noj qab haus huv txuas ntxiv hauv cov metabolic kev noj qab haus huv thiab kev ua kom zoo.
Koj puas tau npaj txhij los ua kev tsim kho?
Cia peb kawm paub ntxiv txog Dihydroberberine!
Siv:
[1] Wang, K., li al. (2020). Dihydroberberine, ib hydrogenated derivative ntawm berberine, txhim kho cov glucose thiab lipid metabolism ntawm ampk ua kom muaj cov nas ej rog.Frontiers hauv Pharmacology, 11, * 573501 *. PMID: 3332421.
[2] Turner, N., li al. (2008). Berberine thiab nws ntau biologically muaj derivative, inhibit mitochondrial ua pa rau amp-activated protein kinase thiab txhim kho insulin nkaus.Ntshav qab zib, 57 (5), 1414-1418. PMID: 18285556.
[3] Pirillo, A., & catapano, al (2015). Berberine, nroj tsuag alkaloid nrog lipid- thiab qab zib-txo thaj chaw: los ntawm hauv cov ntawv pov thawj vress rau kev tshawb fawb hauv chaw soj ntsuam.Atherosclerosis, 243 (2), 449-461. PMID: 26520899.
[4] Ilyas, Z., li al. (2020). Cov nyhuv ntawm berberine ntxiv rau ntawm cov rog tsis, o thiab daim siab ua haujlwm enzymes thiab leta-tsom xam cov kev sim sib xws.Kho Mob Noj Khoom Haus Espen, 38, 43-49. PMID: 32359743.
[5] Zhang, L., li al. (2012). Qhov cuam tshuam ntawm berberine on glucose metabolism hauv vitro thiab hauv vivo.Metabolism, 61 (8), 1028-1038. PMID: 22386934.
[6] Marazzi, G. li al. (2021). Qhov ua tau zoo thiab kev thev taus ntawm cov neeg siv dag zog ua ntej (GlucWantage) hauv Hom 2 Ntshav Qab Zib hom 2: Kev kawm kev sim.
