DNJ - ib qho natrual-close-classidase inhibitor

Dnj (Deoxynojirimycuscuscuscusci yog ib lub ntuj alkaloid pom hauv mulberry (morus albal.). Raws li lub zog-nyem cov inhibitorase inhibitor, DNJ tuaj yeem qeeb qeeb ntawm cov ntshav qab zib, thiab vim li cas DNJ yog hu ua "cov tshuaj insulin". Tsis tas li ntawd, dnj txhim kho cov insulin rhiab heev thiab cov tshuaj insulin tsis kam.

Cov ntsiab lus ntawm DNJ nyob rau hauv mulberry ntoo yog ntau dua li ntawm lwm cov nroj tsuag uas tau pom. DNJ hauv tsob ntoo mulberry feem ntau yog muab faib rau hauv nplooj, keeb kwm, thiab cov ntoo ntawm cov ntsiab lus ntawm cov DNJ (txog ib txhiab ntawm qhov hnyav). Ntxiv mus, Mulberry nplooj account rau cov feem ntau ntawm cov teeb meem qhuav ntawm tag nrho cov ntoo mulberry, txog 65%. Yog li ntawd, mulberry nplooj tau dhau los ua ib qho tseem ceeb ntawm cov DNJ.

• Xyoo 1976, Yoshiaki Nrhiav DnJ Molecules thawj zaug los ntawm cov hauv paus hniav thiab cov ceg ntawm morus alba.
• Xyoo 1994, ASANO li al. Raug rho tawm rau tus alkaloids suav nrog DNJ lwg me me los ntawm nplooj ntawm morus alba.
• Xyoo 1995, Kimura li al. paub tseeb tias DNJ molecules tau muaj qhov tseem ceeb tshaj plaws rau kev mob hlwb. Hauv lwm lo lus, dnj molecule yog cov khoom siv tseem ceeb nyob rau hauv lub hypoglycemic nyhuv ntawm mulberry nplooj.
• Xyoo 1997, Kato txiav txim siab cov qauv molecular ntawm DNJ.
• Xyoo 2023, cia siab rau nws cov teeb meem R & D muaj peev xwm muaj 99.9% kev ua haujlwm ntawm cov teeb meem tshuaj snove, thiab teeb tsa cov qauv kev lag luam tshiab rau DNJ.

Kev txo cov ntshav qab zib

DNJ yog lub ntuj thiab muaj zog -GlucSidor, uas tuaj yeem ua rau muaj kev sib tw me me thiab muaj kev sib tw me me, thiab lwm yam kev sib tw ua rau muaj kev sib tsoo, thiab muaj qhov muaj zog rau cov piam thaj, thiab muaj cov piam thaj ntau yuav tsis nqus tau Tab sis xa mus rau txoj hnyuv loj. Vim tias qhov kev txiav txim ntawm DNJ, cov piam thaj tsawg nkag mus rau theem ntshav, thiab yog li theem ntshav qab ntshav yog tswj hwm ntawm qib noj qab nyob zoo.

Stabilizing kev yoo ntshav qab zib

Cov neeg mob ntshav qab zib, cov hepatic glycogen tau tawg rau hauv cov piam thaj, uas ua rau tsis muaj txiaj ntsig zoo yoo yoo ntshav ntshav zoo siab. DNJ tuaj yeem tiv thaiv cov hepatic ntau dhau los ntawm kev tawg mus rau hauv cov ntshav qab zib muaj txiaj ntsig los ntawm glycogen phosphorlase, yog li ruaj khov kev yoo ntshav qab zib.

Kev Txhim Kho Cov Insulin Kuj

Insulin tsis kam lees hais txog ntau yam laj thawj yog li insulin los txhawb kev ua kom zoo nkauj thiab siv cov tshuaj tsw qab ntau dhau los, cov tshuaj insulin ntau dhau heev. Qhov no tsim cov hyperinsulinemia kom muaj kev ruaj khov ntawm cov ntshav ntshav hauv lub cev.
DNJ muaj peev xwm los txhim kho cov tsos mob ntawm insulin tsis kam los ntawm kev saib xyuas cov ntshav qab noj qab haus huv, thiab cov tshuaj insulin rhiab.

Mulberry nplooj tau siv ntau txhiab xyoo rau cov zaub mov thiab tshuaj kho mob, thiab lawv qhov kev nyab xeeb tau raug sim nyob rau lub sijhawm.

Mulberry nplooj tau pom los ntawm Ministry of Health of Tuam Tshoj xyoo 1993 ua ib hom tsiaj nrog tib qho keeb kwm ntawm cov zaub mov thiab tshuaj. Mulberry nplooj tsis yog tsuas yog muaj cov txiaj ntsig zoo nqi tab sis kuj noj raws li cov khoom noj.

Pharmacogenetic Kev Ntsuam Xyuastau qhia tias DNJ muaj lub sijhawm nyob luv luv hauv tib neeg lub cev uas tsis muaj tshuaj lom. DNJ tsis tas yuav tawg los ntawm daim siab, nws yog excreted nyob rau hauv daim ntawv ntawm tus qauv uas tsis muaj cov khoom lag luam metabolic.

Kev nyab xeeb ntawm DNJ yog kev lees paub ntxiv los ntawm cov txiaj ntsig ntawm aKev Kawm Toxicology (2012)Cov. CyTotoxic thiab Genotoxic Ethanolic Excelolic Extract muaj lub ic50 ntawm 5g / kg lub cev qhov hnyav thiab tsis muaj tshuaj lom tau kuaj hauv cov nas kom noj nrog DNJ.

Koj lub chaw tsim khoom hauv Suav teb koj nyob hauv Suav teb, raws li DNJ hmoov av tsim cov khoom lag luam zoo. Peb txoj kev cog lus rau qhov zoo tshaj plaws yog tshwm sim raws li txhua pob ntawm peb cov hmoov Dnj undergoes nyuaj heev ntawm kev coj dawb huv thiab zoo. Peb koom tes nrog kev ua hauj lwm thib peb tog kom paub meej tias peb cov khoom raws cov qauv nruj.

Raws li DNJ hmoov muag khoom, peb muab cov kev pab cuam OEM tshwj xeeb kom ua tau raws li qhov yuav tsum tau ua kom tau raws li peb cov lus xav tau. Txawm hais tias koj tab tom nrhiav kev txhim kho cov kev daws teeb meem ntxiv lossis xav tau cov hmoov ntim cov hmoov av zoo uas tau pom zoo rau kev coj ua thiab GMP.

Txhawb koj cov khoom kab nrog lub purest form ntawm cov khoom xyaw muaj nyob rau ntawm kev ua lag luam. Tiv tauj peb hnub no kom tau txais ib qho lag luam wholesale DNJ hmoov hais thiab tshawb pom tias peb cov kev daws teeb meem tuaj yeem txhim kho koj cov nyiaj.

Siv:

[1] Lu m, wuz j, et al, et al.mining thiab cim ntawm lub cytochrome hydroxin1bg22 koom nrog Mulberry nplooj [J]. Sethernational Joist of biological MacRomolecules, 2024,282 (P2): 136941-136941.

[2] Ua Jh, Chung Hj, Hwang HJ, li Al.1-Deasynojirismycabycis cais tawm hepatic Lipid metabolism thiab Mice-Fed-Funp-Fun-Functology, 2015,751-7.

[3]Xinxiu R ,Qinfeng G ,Hui J , et al.Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice[J].Phytomedicine,2023,121155106-155106.

[4] MD, Riche DK, East Eh, ET AL.impact ntawm cov ntshav mob ntshav qab zib ntawm hom tshuaj Ntshav (J].

[5] il sl, kyung yl, dong, rong -ffects ntawm cov dej num hauv lub cev thiab cov neeg muaj kev sib koom tes ntawm lub cev muaj zog [J]. 2013) (11): 5646-5657.