Nicotinamide adenine tinucleotide (NAD +)yog ib qho tseem ceeb coenzyme tam sim no nyob rau hauv txhua lub xov tooj uas muaj sia thiab hailed raws li tus"Spark ntsaws ntawm lub cav lub cav"Cov. Nrog kev nce qib ntawm kev tshawb fawb, nws tau lees tias theem NAD + qhov uas cuam tshuam nrog ntau yam kev laus- cov kab mob muaj feem xyuam.
Ntxiv NAD + precursors (xws li nmn lossis nr) kom nce ntxiv ntawm cov khoom noj muaj txiaj ntsig zoo tshaj plaws hauv kev noj qab haus huv, lub zog metabolism, thiab txhawb kev laus.
Dab tsi yog NAD +?
NAD + (Nicotinamide Adenine Tinucleotoide) yog qhov tseem ceeb coenzyme rau ntau pua ntawm cov roj ntsha tseem ceeb hauv lub cev. Nws yog tsuas yog koom nrog ob qho tseem ceeb:
- Ntau Lawm:Hauv Mitochondria, NAD + plays yog lub luag haujlwm tseem ceeb hauv kev hloov cov as-ham hauv cellular (ATP), uas yog lub hauv paus rau kev tswj hwm txhua yam haujlwm ntawm lub cev.
- Tswj cov xovtooj ntawm tes:NAD + yog qhov tsim nyog substrate rau kev ua kom muaj cov proteinity xws li sirtins. Cov protein no ua ib lub luag haujlwm tseem ceeb hauv DNA kho, cov khoom ua yeeb yam ntawm cov kev cai, thiab kev ntxhov siab cellular.
Hauv cov ntsiab lus yooj yim, tsis muaj nad +, lub zog ua haujlwm ntawm lub cell yuav tseg rau kev ua haujlwm, thiab cov txheej txheem uas tswj hwm cov kev noj qab haus huv Genomic thiab kev noj qab haus huv ntawm tes yuav tsis ua haujlwm zoo.
Cov txiaj ntsig ntawm NAD +
Cov tub ntxhais lub zog ntawm Nad + Swirove nyob ib ncig ntawm cellular metabolism thiab kho mob ntawm tes. Ntau cov kev tshawb fawb tau pom tau tias nce NAD nAD + qib tuaj yeem nqa ntau cov txiaj ntsig kev noj qab haus huv.
Ⅰ Txhawb nqa cov metabular zog metabolism hauv lub zog thiab cov combats qaug zog
NAD + yog qhov tseem ceeb electron Carrier nyob rau hauv mitochondrial tricarboxylic acid pain (thiab lub tshuab hluav taws xob
Cov pov thawj scientific:Kev tshawb fawb luam tawm nyob rau hauv "Mine Metabolism" qhia tau tias ntxiv rau cov nas uas muaj kev ntxhov siab thiab lub cev kev ua kom lub cev ua haujlwm thiab lub cev kev ua siab ntev rau theem ntawm cov neeg yau. Qhov no yog qhov tseem ceeb rau kev hais txog lub zog tsis muaj zog los ntawm kev laus lossis nkees.
Ⅱ Txhawb DNA kho thiab tswj hwm Genomic Stability
NAD + yog lub ntsiab saststrate ntawm parp (poly (adp - ribose) polymerase) proteins. PANP ua si lub luag haujlwm tseem ceeb hauv kev tshawb nrhiav thiab kho DNA kev puas tsuaj.
Cov pov thawj scientific:Kev tshawb fawb qhia tau hais tias DNA kev puas tsuaj siv ntau npaum li cas ntawm NAD + nyob rau hauv lub hlwb los qhib parp. Tswj kom muaj ib qib ntawm NAD txaus kom ntseeg tau tias cov lej parp enzyme tuaj yeem ua haujlwm txuas ntxiv thiab muaj txiaj ntsig, yog li tiv thaiv cov kev puas tsuaj los ntawm kev ua kom tsis txaus ntseeg. Nov yog lub hauv paus rau kev tiv thaiv kev laus thiab kab mob.
Ⅲ Ua kom muaj cov protein ntev ntev (sirtater) thiab ncua kev laus ntawm tes
Sirtuins yog chav ua haujlwm ntawm deycetylases uas cia siab rau nad +. Lawv yog cov npe hu ua metabolism "yog qhov feem ntau ze rau metabolism thiab anti -}}}}}}}
Cov pov thawj scientific:Cov pab neeg tshawb fawb los ntawm Harvard School School tau ua kom pom kev noj qab haus huv si + Lwm qhov kev tshawb fawb tau hais tias NAD + tuaj yeem tiv thaiv cov neurons thiab txhim kho cov haujlwm hauv cov qauv ntawm neurodegenerative cov kab mob los ntawm kev ua kom tiav Sirt3.
Txhawb lub hlwb kev noj qab haus huv thiab kev txawj ntse
Lub hlwb yog lub hlwb yog cov metabolism feem ntau hauv tib neeg lub cev thiab muaj kev vam meej ntawm Mitochondrial zog. NAD + yog qhov tseem ceeb rau kev tswj hwm kev noj qab haus huv thiab kev ua haujlwm ntawm neurons.
Cov pov thawj scientific:Hauv cov qauv tsiaj ntawm cov kab mob neurodegenerative cov kab mob xws li Alzheimer tus kab mob, txo qis kev ntxhov siab, thiab txhim kho kev ua haujlwm loj, ua rau muaj peev xwm tseem ceeb, ua rau muaj peev xwm ua yeeb yam tseem ceeb.
Lub tshuab ua haujlwm ntawm NAD +
Cov kws kho tshuab ntawm kev ua ntawm NAD + tsuas yog tig mus ncig nws ob lub luag hauj lwm hauv lub xov tooj ntawm tes:
Ⅰ Redox Redge:NAD + kev ua raws li lub tshuab hluav taws xob hluav taws xob los ntawm kev caij tsheb kauj vab ntawm nws daim ntawv oxidized (nad +) thiab nws daim ntawv txo (nadh). Nws lees txais cov hluav taws xob thaum lub sij hawm catabolism ntawm cov suab thaj, cov rog, thiab cov amino acids rau lub tshuab hluav taws xob mus rau mitochondria los tsim kom muaj ATP. Lub voj voog no yog lub hauv paus rau lub cim ntawm lub cev lub zog nyiaj, ATP.
Ⅱ Ua ib substrate rau kev piav qhia molecules:NAD + yog qhov tsim nyog substrate rau ntau yam tseem ceeb enzymatic cov tshuaj tiv thaiv, thiab cov enzymes no haus nad + los ua lawv cov haujlwm:
- Sirtuins (sirts):Deplete nad + kom tshem cov pab pawg acetyl los ntawm cov protein los ntawm cov protein, yog li cuam tshuam noob gene, kev ntxhov siab thiab metabolism.
- Tsev Loj:Haus NAD + mus rau synthesize adp - nkauj ribose polymers, hauv kev teb rau DNA kev puas tsuaj thiab rau kev kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab rau kev kho kom zoo nkauj thiab kho kom zoo nkauj thiab siv lub hom phiaj.
- CD38 / CD157:Raws li ib qho enzyme, nws noj nad + thiab koom nrog calcium teeb liab transdal thiab kev tiv thaiv kab mob.
Tag
NAD + yog los ntawm tsis muaj txhais tau tias yog cov khoom noj zoo ib yam li. Nws yog qhov tseem ceeb ntawm lub zog thiab kho cov kab ke. Coob tus ntawm kev tshawb fawb txog kev tshawb fawb tau qhia tias tswj hwm qib NAD Los ntawm kev txhawb nqa metabolism thiab lub zog nce qib, txhim kho kev ua haujlwm ntev ntawm Nad + yog qhov tseeb thiab ntau} las} fayed.
Txawm hais tias lub sijhawm ntev - TSHEM UAS YUAV TSUM tau ntau tib neeg kev tshawb fawb kom paub tseeb, cov ntaub ntawv muaj kev nyab xeeb uas twb muaj lawm twb muaj kev txhawb nqa tau txaus. Rau cov neeg siv khoom uas xav ua lag luam hauv kev noj qab haus huv ntawm cov txheej txheem kev noj qab haus huv tshiab thiab sawv cev ntawm kev tshawb fawb txog kev noj qab haus huv, nrog kev ua lag luam loj loj thiab kev ua lag luam loj.
