CA AKG (-Koj lub calcium ntsev) yog cov calcium ntsev ntawm cov tib neeg tricarboxylic acid nyob rau hauv tib neeg lub zog metabolism hauv lub zog thiab yog amino acid synthesis. Nws cov ntsev ntsev ua ke ua ke cov metabolic kev ua si ntawm cov metabolutarate nrog cov calcium ntsev los yog sib npaug rau 6 lub hlis ntawm pH 6.0-8.0).
Raws li ib tiam tshiab ntawm "cov roj cellular", CA AKG tau pom muaj ntau yam kev ua tau zoo, thiab kev ua si tiv thaiv kev noj qab haus huv, thiab kev hloov kho mob hauv zog, epigenetic hloov kho, thiab redox sib npaug.
Kev Tshawb Fawb Txog Ca-Akg Hmoov
Ⅰ Tiv Thaiv Kev Laus & Lub Neej Txuas Ntxiv
- Ua kom kho ampk / mtor av txoj kev:Kev tswj hwm cellular autophagy thiab tshem cov sencescence protein sib sau ua ke (piv txwv li, p62 / sqsm1).
- Inhibition ntawm -ketoglutarate-basent dioxygardase (-kgddddd):Txo DNA hydroxymethylation kev puas tsuaj thiab tswj hwm epigenomic stability.
- Txhawb Nad + Kev tsim dua tshiab:Txhawb cov elecellular nad + ntau ntau ntau los ntawm kev kho cov hluavtaws kho kom zoo thiab ua kom lub sirtuins ntev ntev.
Kev Tshawb Fawb:
- Kev kawm txog kev ua neej ntawm cov qauv tsim qauv: hauv kev ua haujlwm ntawm tes (2014) kawm,
- Thim rov qab Mammalian laus phenotype: Kev sib txuas lus ntawm 20G rov qab los ntawm kev ua haujlwm hauv tsev laus los ntawm kev ua haujlwm ntawm IL-1 (ZHANG LI AL., 2023).
Ⅱ Pab txhim kho lub zog metabolism thiab kev ua haujlwm
- TCA lub voj voog potentiation:CA-AKG raws li qhov tseem ceeb ntawm hauv TCA lub voj voog, nws nrawm dua kev ua haujlwm ntawm mitochondrial ntawm mitochondrial hluav taws xob ntawm mitocondrial ntawm cov piam thaj hauv cov piam thaj ua ke 18%)
- Txo cov lactate tsim:Txhawb kev ua haujlwm ua kom lub voj voog lactate los ntawm Alanine-kua dej qab zib, txo cov ntshav lactate los ntawm nce txog 35% (kuaj 30 feeb tom qab qoj ib ce)
- Txhawb cov ceg saw amino acid (BCAA) metabolism:Qhib BCKDH complex kom nrawm rau oxidative zog muab cov leucine thiab isoleucine
Kev Tshawb Fawb:
- Erhesces ua qoj ib ce: Cov neeg ncaws pob ntxiv nrog 2G ntawm CA AKG txhua hnub rau kev ua kom muaj zog hauv kev tawm dag zog hauv 2021 tau nce mus ua pa phosphochocrume rov qab (powerers li al., 2021).
- Kev rov qab nrawm dua los ntawm kev tawm dag zog: Ib qho kev kawm phau ntawv xov xwm thiab kev kawm ua haujlwm nrog HMB txo qhov kev sib koom ua ke ntawm cov leeg nqaij (HALS) los ntawm 58% (Wilson et al., 2022).
Ⅲ Pob Txha Kev Noj Qab Haus Huv thiab Calcium Synergistor
- Osteooblast ua kom muaj zog:Txhawb txoj kev sib txawv anteamblast sib txawv los ntawm Wnt / -Catenin signaling txoj kev (3.2-khawm ntxiv hauv Alp Kev Ua)
- Osteapas Inhibition:Downregula qeb / opg sib piv los txo cov osteoclast tsim (67% txo ntawm cuab-zoo cells)
- Calcium hom phiaj xa tuaj:QUB tso tawm cov ntsev ntsev hauv Alkaline Txoj Kev Pleev Ib puag ncig, txhim kho calcium bioavailability los txog li 28% (thiab cov calcium carbonate qeeb)
Kev Tshawb Fawb:
- Txhim kho cov osteoporosis: Hauv kev mus kuaj mob 2019 ntawm cov poj niam ntxiv rau 29% nce qib 29% tom qab 6 lub hlis lossis al., 2019).
Ⅳ Immunomodulation & Plab Kev Noj Qab Haus Huv
- T cell metabolic reprroegraming: PRomotes Cim Tell tiam tiam tiam (45% nce hauv cd {} t cell proliferation)
- Kho Kom Txhim Kho Txoj hnyuv:Upregulate atretic Zona Qaug Protein-1 (ZO-1) qhia thiab txo cov hnyuv loj (62% txo qis hauv cov ntshav ntshav siab tshaj plaws ecotoxin)
- Anti-inflammatory cuam tshuam:Inhibition ntawm nlrp3 inflammatory vesrice ua kom thiab 73% txo qis hauv IL-1 kev zais cia
Kev Tshawb Fawb:
- Kev Txhim Kho ntawm Autoimmia Kab Mob: Ib qho kev sim ua ke ntawm 48 kev soj ntsuam kev cuam tshuam cov qhab nees
Ⅴ Antioxidant & Liverprotection
- Glutathione (GSH) PROGURSOR:Ua kom muaj kev hloov pauv hloov pauv thiab txhawb nqa Gsh Synthesis (55% nce hauv Hepatocyte Gsh)
- Ammonia detoxification pathwation:Ua kom nrawm ammonia cov metabolism hauv cov kev urea, txo cov ntshav ammonia concentration los ntawm li 40%.
- NRF2 txoj kev ua kom muaj zog:Upregulates Superoxide dismutase (sod) thiab catalase (miv) qhia
Kev Tshawb Fawb:
- Kev tiv thaiv lub siab: 2022 kev kawm hauv kev siv tshuaj tua kab MDA los ntawm kev haus cawv los ntawm kev haus dej haus rau MDA los ntawm kev haus dej haus cawv / ant
Siv:
1. Lub puab tsaig RM, li al. Cov metabolite -soglutarate txuas ntxiv lub neej ua haujlwm los ntawm inhibiting atp synthease thiab tor. Cell Metabolism, 2014.
2. Zhang X, li al. AKG Restores Cov leeg qia cell ua haujlwm los ntawm IL-1 txoj kev hloov kho. Kev sib txuas lus, 2023.
3. Wang L, li al. HepatoproTspive cuam tshuam ntawm kev tawm tsam cawv cawv-inducction oxidative kev ntxhov siab. Dawb radical biology thiab tshuaj, 2022.
DISCLAIMER: Cov lus no yog rau cov ntaub ntawv dav dav thiab yuav tsum tsis txhob suav tias yog cov lus qhia kev kho mob. Qee cov ntaub ntawv tshaj tawm blog tau los ntawm Is Taws Nem thiab tsis yog kev tshaj lij. Lub vev xaib no tsuas yog lub luag haujlwm rau kev txheeb xyuas, kev tawm tswv yim thiab kho cov lus. Lub hom phiaj ntawm kev xa cov ntaub ntawv ntau ntxiv tsis txhais tau tias koj pom zoo nrog nws cov kev pom lossis paub meej tias qhov tseeb ntawm nws cov ntsiab lus. Yuav tsum sab laj nrog tus kws saib xyuas kev noj qab haus huv ua ntej siv cov tshuaj pab lossis ua cov kev hloov pauv rau koj cov kev kho mob.
